Beyond the Black Box: Reassessing HRT for Modern Women
Viewpoints from Sarah Fleming, PharmD For over two decades, hormone replacement therapy (HRT) has been shadowed by cautionary tales and black box warnings. These warnings – rooted in early interpretations of the Women’s Health Initiative (WHI) – have shaped prescribing habits, patient perceptions, and even formulary decisions. But today, we stand at a pivotal moment in women’s health: it’s time to rethink how we prioritize HRT. The WHI and the Black Box Warning The WHI study, published in 2002, raised alarms about increased risks of breast cancer, stroke, and cardiovascular events associated with estrogen therapy. The U.S. Food …
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